Updated: Sep 30, 2019
Cannabidiol (CBD) is a compound that's primarily found in the cannabis plant. CBD can benefit the body in different ways. This makes it great to use in forms like tinctures, topicals, edibles, and more. Once absorbed, CBD begins to work on the body almost immediately.
This cannabinoid does little binding with either of the two primary cannabinoid receptors (CB1 and CB2). Instead, cannabidiol modulates several non-cannabinoid receptors and ion channels. These include the 5-HT1A (hydroxytryptamine) serotonin receptors, TRPV1 vanilloid receptors, GPR55 orphan receptors and PPARs nuclear receptors.
Cannabidiol is an exogenous plant compound. In order for it to get inside a human cell and bind to a nuclear receptor, it must hitch a ride with a fatty acid binding protein (FABP). These fatty acid binding proteins escort various lipid molecules into a cell’s interior. This allows the cannabidiol to pass through the cell membrane. CBD modulates the receptors on the surface of the nucleus. This regulates mitochondrial activity and gene expression.
CBD also acts through receptor-independent pathways. It delays the re-uptake of endogenous neurotransmitters (ex. anandamide and adenosine). CBD can change the shape of the receptor, therefore it can enhance or inhibit how a receptor transmits a signal.
The phytocannabinoid CBD also has biphasic properties. Biphasic means a substance has one type of effect at a lower dose level of consumption and a different type of effect at an increased level of consumption. These effects are dose dependent.
Another interesting fact about CBD is that as time goes on, you need a lesser dose to achieve the same effects due to cannabinoids being fat-soluble compounds. Your body stores cannabinoids in fat, and slowly releases them so their effects are long-lasting.
It's advisable to consult a physician before using CBD. If you are taking medications, ask how the medications you're on affect the cytochrome P-450 enzyme system.
CBD medicinal properties:
- Antiemetic (reduces nausea and vomiting)
- Anticonvulsant (suppresses seizure activity)
- Antipsychotic (combats psychosis disorders)
- Anti-Inflammatory (battles inflammatory disorders)
- Antioxidant (combats neurodegenerative disorders)
- Anxiolytic / Antidepressant (fights anxiety and depression disorders)
The conditions on this list are either in preclinical trials or have been reported by people that CBD had helped them with their afflictions:
- ADD / ADHD
- ALS (Lou Gehrig's disease)
- Antibiotic Resistance
- Chronic Pain
- Colitis / Crohn's
- Endocrine disorders
- Epilepsy / Seizures
- Heart disease
- Huntington's disease
- Irritable Bowel Syndrome
- Kidney disease
- Liver disease
- Metabolic syndrome
- Mood disorders
- Motion sickness
- MS (Multiple Sclerosis)
- Neuropathic pain
- Parkinson's disease
- Sickle Cell Anemia
- Skin Conditions
- Sleep disorders
- Spinal cord injury
- Stroke / TBI
- Varicose veins